BDBM50248600 CHEMBL462667::N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N-methyl-N-phenylcyclopropane-1,1-dicarboxamide

SMILES: CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1

InChI Key: InChIKey=CDNLCCFEKDHCTK-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248600   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248600 (CHEMBL462667 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C29H24FN5O3S/c1-34-16-22(32-17-34)25-15-21-26(39-25)24(10-13-31-21)38-23-9-8-18(14-20(23)30)33-27(36)29(11-12-29)28(37)35(2)19-6-4-3-5-7-19/h3-10,13-17H,11-12H2,1-2H3,(H,33,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins...				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248600 (CHEMBL462667 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C29H24FN5O3S/c1-34-16-22(32-17-34)25-15-21-26(39-25)24(10-13-31-21)38-23-9-8-18(14-20(23)30)33-27(36)29(11-12-29)28(37)35(2)19-6-4-3-5-7-19/h3-10,13-17H,11-12H2,1-2H3,(H,33,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248600 (CHEMBL462667 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C29H24FN5O3S/c1-34-16-22(32-17-34)25-15-21-26(39-25)24(10-13-31-21)38-23-9-8-18(14-20(23)30)33-27(36)29(11-12-29)28(37)35(2)19-6-4-3-5-7-19/h3-10,13-17H,11-12H2,1-2H3,(H,33,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50248600 (CHEMBL462667 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C29H24FN5O3S/c1-34-16-22(32-17-34)25-15-21-26(39-25)24(10-13-31-21)38-23-9-8-18(14-20(23)30)33-27(36)29(11-12-29)28(37)35(2)19-6-4-3-5-7-19/h3-10,13-17H,11-12H2,1-2H3,(H,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair