BDBM50248601 CHEMBL518209::N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1-phenylpyrrolidine-3-carboxamide

SMILES: Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1

InChI Key: InChIKey=MTBUICNMPXYSAM-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248601   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248601 (CHEMBL518209 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-33-15-22(31-16-33)25-14-21-26(38-25)24(9-11-30-21)37-23-8-7-17(13-20(23)29)32-27(35)19-10-12-34(28(19)36)18-5-3-2-4-6-18/h2-9,11,13-16,19H,10,12H2,1H3,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins...				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248601 (CHEMBL518209 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-33-15-22(31-16-33)25-14-21-26(38-25)24(9-11-30-21)37-23-8-7-17(13-20(23)29)32-27(35)19-10-12-34(28(19)36)18-5-3-2-4-6-18/h2-9,11,13-16,19H,10,12H2,1H3,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248601 (CHEMBL518209 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-33-15-22(31-16-33)25-14-21-26(38-25)24(9-11-30-21)37-23-8-7-17(13-20(23)29)32-27(35)19-10-12-34(28(19)36)18-5-3-2-4-6-18/h2-9,11,13-16,19H,10,12H2,1H3,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50248601 (CHEMBL518209 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...) Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-33-15-22(31-16-33)25-14-21-26(38-25)24(9-11-30-21)37-23-8-7-17(13-20(23)29)32-27(35)19-10-12-34(28(19)36)18-5-3-2-4-6-18/h2-9,11,13-16,19H,10,12H2,1H3,(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair