BDBM50249189 CHEMBL4071084

SMILES: Cc1nc(ccc1[C@@H](O)CN1CCC2(CCN(C2=O)c2ccc(=O)n(C)n2)CC1)-n1cnnn1

InChI Key: InChIKey=FXHDTKSOIDFQOT-KRWDZBQOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50249189 (CHEMBL4071084) Show SMILES Cc1nc(ccc1[C@@H](O)CN1CCC2(CCN(C2=O)c2ccc(=O)n(C)n2)CC1)-n1cnnn1 |r| Show InChI InChI=1S/C22H27N9O3/c1-15-16(3-4-18(24-15)31-14-23-26-27-31)17(32)13-29-10-7-22(8-11-29)9-12-30(21(22)34)19-5-6-20(33)28(2)25-19/h3-6,14,17,32H,7-13H2,1-2H3/t17-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Displacement of [35S]MK499 from human ERG expressed in HEK293 cells				Bioorg Med Chem Lett 27: 2559-2566 (2017) Article DOI: 10.1016/j.bmcl.2017.03.086 BindingDB Entry DOI: 10.7270/Q2BV7K1G
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50249189 (CHEMBL4071084) Show SMILES Cc1nc(ccc1[C@@H](O)CN1CCC2(CCN(C2=O)c2ccc(=O)n(C)n2)CC1)-n1cnnn1 |r| Show InChI InChI=1S/C22H27N9O3/c1-15-16(3-4-18(24-15)31-14-23-26-27-31)17(32)13-29-10-7-22(8-11-29)9-12-30(21(22)34)19-5-6-20(33)28(2)25-19/h3-6,14,17,32H,7-13H2,1-2H3/t17-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay				Bioorg Med Chem Lett 27: 2559-2566 (2017) Article DOI: 10.1016/j.bmcl.2017.03.086 BindingDB Entry DOI: 10.7270/Q2BV7K1G
					More data for this Ligand-Target Pair