Found 6 hits for monomerid = 50249265 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM50249265
((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)Show SMILES C[C@](N)(COP(O)(O)=O)c1nc(c[nH]1)-c1ccc(OCCc2ccc(cc2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C26H28N3O5P/c1-26(27,18-34-35(30,31)32)25-28-17-24(29-25)22-11-13-23(14-12-22)33-16-15-19-7-9-21(10-8-19)20-5-3-2-4-6-20/h2-14,17H,15-16,18,27H2,1H3,(H,28,29)(H2,30,31,32)/t26-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Praecis Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor |
Bioorg Med Chem Lett 19: 2315-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.073 BindingDB Entry DOI: 10.7270/Q2XD11KJ |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 3
(Homo sapiens (Human)) | BDBM50249265
((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)Show SMILES C[C@](N)(COP(O)(O)=O)c1nc(c[nH]1)-c1ccc(OCCc2ccc(cc2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C26H28N3O5P/c1-26(27,18-34-35(30,31)32)25-28-17-24(29-25)22-11-13-23(14-12-22)33-16-15-19-7-9-21(10-8-19)20-5-3-2-4-6-20/h2-14,17H,15-16,18,27H2,1H3,(H,28,29)(H2,30,31,32)/t26-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Praecis Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor |
Bioorg Med Chem Lett 19: 2315-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.073 BindingDB Entry DOI: 10.7270/Q2XD11KJ |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 5
(Homo sapiens (Human)) | BDBM50249265
((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)Show SMILES C[C@](N)(COP(O)(O)=O)c1nc(c[nH]1)-c1ccc(OCCc2ccc(cc2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C26H28N3O5P/c1-26(27,18-34-35(30,31)32)25-28-17-24(29-25)22-11-13-23(14-12-22)33-16-15-19-7-9-21(10-8-19)20-5-3-2-4-6-20/h2-14,17H,15-16,18,27H2,1H3,(H,28,29)(H2,30,31,32)/t26-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 207 | n/a | n/a | n/a | n/a | n/a | n/a |
Praecis Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor |
Bioorg Med Chem Lett 19: 2315-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.073 BindingDB Entry DOI: 10.7270/Q2XD11KJ |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 3
(Homo sapiens (Human)) | BDBM50249265
((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)Show SMILES C[C@](N)(COP(O)(O)=O)c1nc(c[nH]1)-c1ccc(OCCc2ccc(cc2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C26H28N3O5P/c1-26(27,18-34-35(30,31)32)25-28-17-24(29-25)22-11-13-23(14-12-22)33-16-15-19-7-9-21(10-8-19)20-5-3-2-4-6-20/h2-14,17H,15-16,18,27H2,1H3,(H,28,29)(H2,30,31,32)/t26-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 54.8 | n/a | n/a | n/a | n/a |
Praecis Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding |
Bioorg Med Chem Lett 19: 2315-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.073 BindingDB Entry DOI: 10.7270/Q2XD11KJ |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50249265
((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)Show SMILES C[C@](N)(COP(O)(O)=O)c1nc(c[nH]1)-c1ccc(OCCc2ccc(cc2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C26H28N3O5P/c1-26(27,18-34-35(30,31)32)25-28-17-24(29-25)22-11-13-23(14-12-22)33-16-15-19-7-9-21(10-8-19)20-5-3-2-4-6-20/h2-14,17H,15-16,18,27H2,1H3,(H,28,29)(H2,30,31,32)/t26-/m0/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Praecis Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor |
Bioorg Med Chem Lett 19: 2315-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.073 BindingDB Entry DOI: 10.7270/Q2XD11KJ |
More data for this Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM50249265
((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)Show SMILES C[C@](N)(COP(O)(O)=O)c1nc(c[nH]1)-c1ccc(OCCc2ccc(cc2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C26H28N3O5P/c1-26(27,18-34-35(30,31)32)25-28-17-24(29-25)22-11-13-23(14-12-22)33-16-15-19-7-9-21(10-8-19)20-5-3-2-4-6-20/h2-14,17H,15-16,18,27H2,1H3,(H,28,29)(H2,30,31,32)/t26-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
Praecis Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS binding |
Bioorg Med Chem Lett 19: 2315-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.073 BindingDB Entry DOI: 10.7270/Q2XD11KJ |
More data for this Ligand-Target Pair | |