BDBM50249659 3-acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-methylquinolin-4(1H)-one::CHEMBL523822

SMILES: CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Br)cc1Br

InChI Key: InChIKey=YIRUASIRQWZPIZ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50249659   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calpain1 (Homo sapiens (Human))	BDBM50249659 (3-acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-met...) Show SMILES CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Br)cc1Br Show InChI InChI=1S/C18H13Br2ClN2O2/c1-8-3-5-12(21)16-14(8)17(25)15(9(2)24)18(23-16)22-13-6-4-10(19)7-11(13)20/h3-7H,1-2H3,(H2,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	277	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrate				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair
Calpain1 (Homo sapiens (Human))	BDBM50249659 (3-acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-met...) Show SMILES CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Br)cc1Br Show InChI InChI=1S/C18H13Br2ClN2O2/c1-8-3-5-12(21)16-14(8)17(25)15(9(2)24)18(23-16)22-13-6-4-10(19)7-11(13)20/h3-7H,1-2H3,(H2,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human erythrocytes mu-calpain by fluorometric assay using pep2 as substrate				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50249659 (3-acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-met...) Show SMILES CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Br)cc1Br Show InChI InChI=1S/C18H13Br2ClN2O2/c1-8-3-5-12(21)16-14(8)17(25)15(9(2)24)18(23-16)22-13-6-4-10(19)7-11(13)20/h3-7H,1-2H3,(H2,22,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin D after 30 mins by fluorometric end-point assay				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50249659 (3-acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-met...) Show SMILES CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Br)cc1Br Show InChI InChI=1S/C18H13Br2ClN2O2/c1-8-3-5-12(21)16-14(8)17(25)15(9(2)24)18(23-16)22-13-6-4-10(19)7-11(13)20/h3-7H,1-2H3,(H2,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L after 30 mins by fluorometric end-point assay				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair
Pro-cathepsin H (Homo sapiens (Human))	BDBM50249659 (3-acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-met...) Show SMILES CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Br)cc1Br Show InChI InChI=1S/C18H13Br2ClN2O2/c1-8-3-5-12(21)16-14(8)17(25)15(9(2)24)18(23-16)22-13-6-4-10(19)7-11(13)20/h3-7H,1-2H3,(H2,22,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assay				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50249659 (3-acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-met...) Show SMILES CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Br)cc1Br Show InChI InChI=1S/C18H13Br2ClN2O2/c1-8-3-5-12(21)16-14(8)17(25)15(9(2)24)18(23-16)22-13-6-4-10(19)7-11(13)20/h3-7H,1-2H3,(H2,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin B after 30 mins by fluorometric end-point assay				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair