BDBM50249668 6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione::CHEMBL454734
SMILES: OC[C@H]1O[C@@H](On2c3cc(O)ccc3c3c4C(=O)N(NCc5ccccc5)C(=O)c4c4c5ccc(O)cc5[nH]c4c23)[C@H](O)[C@@H](O)[C@@H]1O
InChI Key: InChIKey=CHVZOWCOGXNDSX-OJSVXGLKSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 1 (Mus musculus) | BDBM50249668 (6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by protinase K/SDS method | J Med Chem 52: 3225-37 (2009) Article DOI: 10.1021/jm801641t BindingDB Entry DOI: 10.7270/Q23F4PJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50249668 (6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometer | J Med Chem 52: 3225-37 (2009) Article DOI: 10.1021/jm801641t BindingDB Entry DOI: 10.7270/Q23F4PJ0 | |||||||||||
More data for this Ligand-Target Pair |