null

SMILES: OC[C@H]1O[C@@H](On2c3cc(O)ccc3c3c4C(=O)N(NCc5ccnc6ccccc56)C(=O)c4c4c5ccc(O)cc5[nH]c4c23)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key: InChIKey=AZIQUAHDYZVKOG-PFELOJGESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249678   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50249678 (2,10-Dihydroxy-6-[(quinolin-4-ylmethyl)amino]-13-(...) Show SMILES OC[C@H]1O[C@@H](On2c3cc(O)ccc3c3c4C(=O)N(NCc5ccnc6ccccc56)C(=O)c4c4c5ccc(O)cc5[nH]c4c23)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C36H29N5O10/c42-14-24-31(45)32(46)33(47)36(50-24)51-41-23-12-17(44)6-8-20(23)26-28-27(25-19-7-5-16(43)11-22(19)39-29(25)30(26)41)34(48)40(35(28)49)38-13-15-9-10-37-21-4-2-1-3-18(15)21/h1-12,24,31-33,36,38-39,42-47H,13-14H2/t24-,31-,32+,33-,36+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometer				J Med Chem 52: 3225-37 (2009) Article DOI: 10.1021/jm801641t BindingDB Entry DOI: 10.7270/Q23F4PJ0
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Mus musculus)	BDBM50249678 (2,10-Dihydroxy-6-[(quinolin-4-ylmethyl)amino]-13-(...) Show SMILES OC[C@H]1O[C@@H](On2c3cc(O)ccc3c3c4C(=O)N(NCc5ccnc6ccccc56)C(=O)c4c4c5ccc(O)cc5[nH]c4c23)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C36H29N5O10/c42-14-24-31(45)32(46)33(47)36(50-24)51-41-23-12-17(44)6-8-20(23)26-28-27(25-19-7-5-16(43)11-22(19)39-29(25)30(26)41)34(48)40(35(28)49)38-13-15-9-10-37-21-4-2-1-3-18(15)21/h1-12,24,31-33,36,38-39,42-47H,13-14H2/t24-,31-,32+,33-,36+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by protinase K/SDS method				J Med Chem 52: 3225-37 (2009) Article DOI: 10.1021/jm801641t BindingDB Entry DOI: 10.7270/Q23F4PJ0
					More data for this Ligand-Target Pair