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BDBM50249708 CHEMBL4096964

SMILES: CCCCNc1nc(N)nc2ccn(Cc3ccccn3)c12

InChI Key: InChIKey=BCLAUIYTXNBJSA-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249708   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))		BDBM50249708
PNG
(CHEMBL4096964)
Show SMILES CCCCNc1nc(N)nc2ccn(Cc3ccccn3)c12
Show InChI InChI=1S/C16H20N6/c1-2-3-8-19-15-14-13(20-16(17)21-15)7-10-22(14)11-12-6-4-5-9-18-12/h4-7,9-10H,2-3,8,11H2,1H3,(H3,17,19,20,21)
PDB

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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 60n/an/an/an/a



Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of IFNalpha-mediated inhibition of HCV genotype 1b RNA replication in human HuH luc/neo ...

J Med Chem 60: 6137-6151 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00365
BindingDB Entry DOI: 10.7270/Q2XP77CC
More data for this
Ligand-Target Pair