BDBM50249716 CHEMBL4101498

SMILES: COCCNc1nc(N)nc2ccn(Cc3ccccn3)c12

InChI Key: InChIKey=FQOOIYBSYGJQTA-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249716   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50249716 (CHEMBL4101498) Show SMILES COCCNc1nc(N)nc2ccn(Cc3ccccn3)c12 Show InChI InChI=1S/C15H18N6O/c1-22-9-7-18-14-13-12(19-15(16)20-14)5-8-21(13)10-11-4-2-3-6-17-11/h2-6,8H,7,9-10H2,1H3,(H3,16,18,19,20)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a
Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium. Curated by ChEMBL					Assay Description Agonist activity at TLR7 in human PBMC assessed as induction of IFNalpha-mediated inhibition of HCV genotype 1b RNA replication in human HuH luc/neo ...				J Med Chem 60: 6137-6151 (2017) Article DOI: 10.1021/acs.jmedchem.7b00365 BindingDB Entry DOI: 10.7270/Q2XP77CC
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