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BDBM50249721 CHEMBL4061921

SMILES: Cc1nnc(CNc2nc(N)nc3ccn(Cc4ccccn4)c23)o1

InChI Key: InChIKey=JSNWKBXJWOMCJF-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249721   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))		BDBM50249721
PNG
(CHEMBL4061921)
Show SMILES Cc1nnc(CNc2nc(N)nc3ccn(Cc4ccccn4)c23)o1
Show InChI InChI=1S/C16H16N8O/c1-10-22-23-13(25-10)8-19-15-14-12(20-16(17)21-15)5-7-24(14)9-11-4-2-3-6-18-11/h2-7H,8-9H2,1H3,(H3,17,19,20,21)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 90n/an/an/an/a



Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of IFNalpha-mediated inhibition of HCV genotype 1b RNA replication in human HuH luc/neo ...

J Med Chem 60: 6137-6151 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00365
BindingDB Entry DOI: 10.7270/Q2XP77CC
More data for this
Ligand-Target Pair