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SMILES: CN(CCO)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23

InChI Key: InChIKey=YNCNPACQCPGDEK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50251129   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50251129 (7-Chloro-2-{2-[(2-hydroxy-ethyl)-methyl-amino]-eth...) Show SMILES CN(CCO)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23 Show InChI InChI=1S/C19H18ClN3O2/c1-22(10-11-24)8-9-23-15-7-3-5-13-17(15)18(21-23)12-4-2-6-14(20)16(12)19(13)25/h2-7,24H,8-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manitoba Curated by ChEMBL					Assay Description Inhibition of decatenation activity of human topoisomerase 2alpha				Bioorg Med Chem 17: 4575-82 (2009) Article DOI: 10.1016/j.bmc.2009.04.072 BindingDB Entry DOI: 10.7270/Q28915XR
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50251129 (7-Chloro-2-{2-[(2-hydroxy-ethyl)-methyl-amino]-eth...) Show SMILES CN(CCO)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23 Show InChI InChI=1S/C19H18ClN3O2/c1-22(10-11-24)8-9-23-15-7-3-5-13-17(15)18(21-23)12-4-2-6-14(20)16(12)19(13)25/h2-7,24H,8-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manitoba Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha decantation activity				Bioorg Med Chem 16: 3959-68 (2008) Article DOI: 10.1016/j.bmc.2008.01.033 BindingDB Entry DOI: 10.7270/Q2T72H7K
					More data for this Ligand-Target Pair