BDBM50251224 CHEMBL4073431

SMILES: CC1N(C)c2ccc(Cl)cc2S(=O)(=O)N1C

InChI Key: InChIKey=KKDTTWULFNGREK-UHFFFAOYSA-N

Data: 2 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50251224   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor AMPA 1/2 (Homo sapiens (Human))	BDBM50251224 (CHEMBL4073431) Show SMILES CC1N(C)c2ccc(Cl)cc2S(=O)(=O)N1C Show InChI InChI=1S/C10H13ClN2O2S/c1-7-12(2)9-5-4-8(11)6-10(9)16(14,15)13(7)3/h4-7H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Quartier Hôpital B36 Av. Hippocrate 15 B-4000 Liège, Belgium. Curated by ChEMBL					Assay Description Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...				J Med Chem 61: 251-264 (2018) Article DOI: 10.1021/acs.jmedchem.7b01323 BindingDB Entry DOI: 10.7270/Q2Z89FV2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor AMPA 2/3 (Homo sapiens (Human))	BDBM50251224 (CHEMBL4073431) Show SMILES CC1N(C)c2ccc(Cl)cc2S(=O)(=O)N1C Show InChI InChI=1S/C10H13ClN2O2S/c1-7-12(2)9-5-4-8(11)6-10(9)16(14,15)13(7)3/h4-7H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Quartier Hôpital B36 Av. Hippocrate 15 B-4000 Liège, Belgium. Curated by ChEMBL					Assay Description Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...				J Med Chem 61: 251-264 (2018) Article DOI: 10.1021/acs.jmedchem.7b01323 BindingDB Entry DOI: 10.7270/Q2Z89FV2
					More data for this Ligand-Target Pair				3D Structure (crystal)