BDBM50251264 CHEMBL4059688

SMILES: ONC(=O)\C=C\c1ccc(cc1)C(=O)N(Cc1ccc2cc(Br)ccc2n1)c1ccccc1

InChI Key: InChIKey=SYCFQVFYALHQRX-OVCLIPMQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251264   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50251264 (CHEMBL4059688) Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(=O)N(Cc1ccc2cc(Br)ccc2n1)c1ccccc1 Show InChI InChI=1S/C26H20BrN3O3/c27-21-12-14-24-20(16-21)11-13-22(28-24)17-30(23-4-2-1-3-5-23)26(32)19-9-6-18(7-10-19)8-15-25(31)29-33/h1-16,33H,17H2,(H,29,31)/b15-8+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, 250012 Jinan, Shandong, P Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cell nuclear extract using COLOR DE LYS as substrate pretreated for 5 mins followed by substrate addition measure...				Eur J Med Chem 133: 11-23 (2017) Article DOI: 10.1016/j.ejmech.2017.03.064 BindingDB Entry DOI: 10.7270/Q2PV6NTB
					More data for this Ligand-Target Pair