BDBM50251271 CHEMBL4082580

SMILES: COc1ccc(cc1)N(Cc1ccc2ccccc2n1)C(=O)c1ccc(\C=C\C(=O)NO)cc1

InChI Key: InChIKey=URGOAULLESKZPK-CAOOACKPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251271   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1/2 (Homo sapiens (Human))	BDBM50251271 (CHEMBL4082580) Show SMILES COc1ccc(cc1)N(Cc1ccc2ccccc2n1)C(=O)c1ccc(\C=C\C(=O)NO)cc1 Show InChI InChI=1S/C27H23N3O4/c1-34-24-15-13-23(14-16-24)30(18-22-12-11-20-4-2-3-5-25(20)28-22)27(32)21-9-6-19(7-10-21)8-17-26(31)29-33/h2-17,33H,18H2,1H3,(H,29,31)/b17-8+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	744	n/a	n/a	n/a	n/a	n/a	n/a
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, 250012 Jinan, Shandong, P Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cell nuclear extract using COLOR DE LYS as substrate pretreated for 5 mins followed by substrate addition measure...				Eur J Med Chem 133: 11-23 (2017) Article DOI: 10.1016/j.ejmech.2017.03.064 BindingDB Entry DOI: 10.7270/Q2PV6NTB
					More data for this Ligand-Target Pair