BDBM50251647 1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-yloxy)-pyridin-3-yl]-amide::CHEMBL516452

SMILES: Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1

InChI Key: InChIKey=SMRGPXRMTZVWME-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50251647   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Antagonist activity at human cloned 5HT2C receptor expressed in CHO cell assessed as blockade of 5HT-stimulated [35S]GTPgammaS binding				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human cloned 5HT2A receptor				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human cloned dopamine D2 receptor				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human cloned dopamine D3 receptor				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human cloned dopamine D4 receptor				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50251647 (1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...) Show SMILES Clc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1 Show InChI InChI=1S/C19H13ClN4O2/c20-18-16(6-3-9-21-18)26-17-8-7-12(10-23-17)24-19(25)14-11-22-15-5-2-1-4-13(14)15/h1-11,22H,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human cloned 5HT7 receptor				Bioorg Med Chem Lett 18: 3844-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.064 BindingDB Entry DOI: 10.7270/Q2P84BQN
					More data for this Ligand-Target Pair