BDBM50251959 2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-hydroxy-2,3-dihydrothiazol-4-yl)acetic acid::CHEMBL520935
SMILES: CC(C)(C)c1ccc(CS(=O)(=O)CC(=O)N=c2scc(CC(O)=O)n2O)cc1
InChI Key: InChIKey=POIZOEYDEHXVML-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Egl nine homolog 1 (Homo sapiens (Human)) | BDBM50251959 (2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay | Bioorg Med Chem Lett 18: 3925-8 (2008) Article DOI: 10.1016/j.bmcl.2008.06.031 BindingDB Entry DOI: 10.7270/Q2XW4JM5 | |||||||||||
More data for this Ligand-Target Pair |