BDBM50253977 1-(1-methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-5-yl)-3-phenylurea::CHEMBL462694

SMILES: Cn1nc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)N1CCCCC1

InChI Key: InChIKey=YTGOQZGHNWFRQP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50253977   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM50253977 (1-(1-methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)N1CCCCC1 Show InChI InChI=1S/C16H21N5O3S/c1-20-14(18-16(22)17-13-8-4-2-5-9-13)12-15(19-20)25(23,24)21-10-6-3-7-11-21/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3,(H2,17,18,22)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of endothelial lipase (unknown origin)				Bioorg Med Chem Lett 19: 27-30 (2008) Article DOI: 10.1016/j.bmcl.2008.11.033 BindingDB Entry DOI: 10.7270/Q2BP02NZ
					More data for this Ligand-Target Pair
Lipoprotein lipase (Rattus norvegicus)	BDBM50253977 (1-(1-methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)N1CCCCC1 Show InChI InChI=1S/C16H21N5O3S/c1-20-14(18-16(22)17-13-8-4-2-5-9-13)12-15(19-20)25(23,24)21-10-6-3-7-11-21/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3,(H2,17,18,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of Lipoprotein lipase from adipose tissue of rat				Bioorg Med Chem Lett 19: 27-30 (2008) Article DOI: 10.1016/j.bmcl.2008.11.033 BindingDB Entry DOI: 10.7270/Q2BP02NZ
					More data for this Ligand-Target Pair