BDBM50254589 1-(4-benzamido-2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-N,N-dibutyl-4-chloro-5-methyl-1H-pyrazole-3-carboxamide::CHEMBL446802

SMILES: CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(NC(=O)c2ccccc2)cc1C(=O)N1CCc2ccccc2C1

InChI Key: InChIKey=ZSAFZGXHHLMXSO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50254589   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM50254589 (1-(4-benzamido-2-(1,2,3,4-tetrahydroisoquinoline-2...) Show SMILES CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(NC(=O)c2ccccc2)cc1C(=O)N1CCc2ccccc2C1 Show InChI InChI=1S/C36H40ClN5O3/c1-4-6-20-40(21-7-5-2)36(45)33-32(37)25(3)42(39-33)31-18-17-29(38-34(43)27-14-9-8-10-15-27)23-30(31)35(44)41-22-19-26-13-11-12-16-28(26)24-41/h8-18,23H,4-7,19-22,24H2,1-3H3,(H,38,43)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Celltech Curated by ChEMBL					Assay Description Inhibition of GST fused Bcl-2 (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assay				Bioorg Med Chem Lett 19: 230-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.113 BindingDB Entry DOI: 10.7270/Q29023MG
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM50254589 (1-(4-benzamido-2-(1,2,3,4-tetrahydroisoquinoline-2...) Show SMILES CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(NC(=O)c2ccccc2)cc1C(=O)N1CCc2ccccc2C1 Show InChI InChI=1S/C36H40ClN5O3/c1-4-6-20-40(21-7-5-2)36(45)33-32(37)25(3)42(39-33)31-18-17-29(38-34(43)27-14-9-8-10-15-27)23-30(31)35(44)41-22-19-26-13-11-12-16-28(26)24-41/h8-18,23H,4-7,19-22,24H2,1-3H3,(H,38,43)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
UCB Celltech Curated by ChEMBL					Assay Description Inhibition of GST fused Bcl-2 (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assay				Bioorg Med Chem Lett 19: 230-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.113 BindingDB Entry DOI: 10.7270/Q29023MG
					More data for this Ligand-Target Pair