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BDBM50254862 CHEMBL4085397

SMILES: Cc1cc(Nc2cc(Cl)c(OC(F)F)c(Cl)c2)nc(N)n1

InChI Key: InChIKey=RQIDLSBVCAADGG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50254862   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
S-adenosylmethionine decarboxylase 1


(Homo sapiens (Human))		BDBM50254862
PNG
(CHEMBL4085397)
Show SMILES Cc1cc(Nc2cc(Cl)c(OC(F)F)c(Cl)c2)nc(N)n1
Show InChI InChI=1S/C12H10Cl2F2N4O/c1-5-2-9(20-12(17)18-5)19-6-3-7(13)10(8(14)4-6)21-11(15)16/h2-4,11H,1H3,(H3,17,18,19,20)
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Article
PubMed
n/an/a>6.30E+4n/an/an/an/an/an/a



Scynexis, Inc. (now Avista Pharma Solutions) , 3501 Tricenter Boulevard, Suite C, Durham, North Carolina 27713, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal His6-tagged AdoMetDC expressed in Escherichia coli BL21/DE3 cells at pH 7.2 by RapidFire-MS-based enzyme a...

J Med Chem 61: 1182-1203 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01654
BindingDB Entry DOI: 10.7270/Q22N54R6
More data for this
Ligand-Target Pair