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SMILES: CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc(Cl)ccc1Cl

InChI Key: InChIKey=URIQQAITZKQZMQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50254928   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))
BDBM50254928
PNG
((7-(2,5-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc(Cl)ccc1Cl |t:1|
Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-22(24(33)31-12-10-30(11-13-31)18-5-3-17(27)4-6-18)23(32-21(29-15)8-9-28-32)19-14-16(25)2-7-20(19)26/h2-9,14,22-23H,10-13H2,1H3
PDB

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PC sid
UniChem

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Similars

Article
PubMed
n/an/a 820n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair