null

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CCCC4)c3n2)c2ccccc2Cl)cc1C

InChI Key: InChIKey=XPMWGTNAXLLKKV-MHZLTWQESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50255858   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50255858 (CHEMBL4084868) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CCCC4)c3n2)c2ccccc2Cl)cc1C |r| Show InChI InChI=1S/C34H41ClN8O2/c1-23-19-26(11-12-29(23)40-17-15-39(2)16-18-40)37-33-36-20-25-21-42(30-10-6-5-9-28(30)35)34(45)43(31(25)38-33)27-13-14-41(22-27)32(44)24-7-3-4-8-24/h5-6,9-12,19-20,24,27H,3-4,7-8,13-18,21-22H2,1-2H3,(H,36,37,38)/t27-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50255858 (CHEMBL4084868) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CCCC4)c3n2)c2ccccc2Cl)cc1C |r| Show InChI InChI=1S/C34H41ClN8O2/c1-23-19-26(11-12-29(23)40-17-15-39(2)16-18-40)37-33-36-20-25-21-42(30-10-6-5-9-28(30)35)34(45)43(31(25)38-33)27-13-14-41(22-27)32(44)24-7-3-4-8-24/h5-6,9-12,19-20,24,27H,3-4,7-8,13-18,21-22H2,1-2H3,(H,36,37,38)/t27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair