null
SMILES: CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)c1cc(OC)ccc1F
InChI Key: InChIKey=HCJQCTLLGILCCL-DEOSSOPVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human)) | BDBM50255934 (CHEMBL4095071) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL | Assay Description Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af... | J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50255934 (CHEMBL4095071) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL | Assay Description Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su... | J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB | |||||||||||
More data for this Ligand-Target Pair |