BDBM50255948 CHEMBL4078026

SMILES: CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C(C)=O)c(C)c3)nc12)c1cc(OC)ccc1F

InChI Key: InChIKey=VXMSGATWEXTLLW-VWLOTQADSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50255948   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50255948 (CHEMBL4078026) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C(C)=O)c(C)c3)nc12)c1cc(OC)ccc1F |r| Show InChI InChI=1S/C33H39FN8O4/c1-5-30(44)40-11-10-25(20-40)42-31-23(19-41(33(42)45)29-17-26(46-4)7-8-27(29)34)18-35-32(37-31)36-24-6-9-28(21(2)16-24)39-14-12-38(13-15-39)22(3)43/h6-9,16-18,25H,5,10-15,19-20H2,1-4H3,(H,35,36,37)/t25-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50255948 (CHEMBL4078026) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C(C)=O)c(C)c3)nc12)c1cc(OC)ccc1F |r| Show InChI InChI=1S/C33H39FN8O4/c1-5-30(44)40-11-10-25(20-40)42-31-23(19-41(33(42)45)29-17-26(46-4)7-8-27(29)34)18-35-32(37-31)36-24-6-9-28(21(2)16-24)39-14-12-38(13-15-39)22(3)43/h6-9,16-18,25H,5,10-15,19-20H2,1-4H3,(H,35,36,37)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair