BDBM50255959 4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1H-imidazol-2-amine::CHEMBL480742

SMILES: Cc1nc(ccc1F)-c1nc(N)[nH]c1-c1ccc2nccnc2c1

InChI Key: InChIKey=AZDQJYNHHKSZIJ-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50255959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50255959 (4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin-6-...) Show SMILES Cc1nc(ccc1F)-c1nc(N)[nH]c1-c1ccc2nccnc2c1 Show InChI InChI=1S/C17H13FN6/c1-9-11(18)3-5-13(22-9)16-15(23-17(19)24-16)10-2-4-12-14(8-10)21-7-6-20-12/h2-8H,1H3,(H3,19,23,24)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbot Laboratories Curated by ChEMBL					Assay Description Binding affinity to human TGFBR1				Bioorg Med Chem Lett 19: 912-6 (2009) Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50255959 (4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin-6-...) Show SMILES Cc1nc(ccc1F)-c1nc(N)[nH]c1-c1ccc2nccnc2c1 Show InChI InChI=1S/C17H13FN6/c1-9-11(18)3-5-13(22-9)16-15(23-17(19)24-16)10-2-4-12-14(8-10)21-7-6-20-12/h2-8H,1H3,(H3,19,23,24)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbot Laboratories Curated by ChEMBL					Assay Description Inhibition of p38alpha (unknown origin)				Bioorg Med Chem Lett 19: 912-6 (2009) Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50255959 (4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin-6-...) Show SMILES Cc1nc(ccc1F)-c1nc(N)[nH]c1-c1ccc2nccnc2c1 Show InChI InChI=1S/C17H13FN6/c1-9-11(18)3-5-13(22-9)16-15(23-17(19)24-16)10-2-4-12-14(8-10)21-7-6-20-12/h2-8H,1H3,(H3,19,23,24)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33.5	n/a	n/a	n/a	n/a	n/a	n/a
Abbot Laboratories Curated by ChEMBL					Assay Description Inhibition of TGFBR1 (unknown origin) transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assay				Bioorg Med Chem Lett 19: 912-6 (2009) Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C
					More data for this Ligand-Target Pair