BDBM50256143 CHEMBL4079300

SMILES: COc1cccc(Nc2cc(nc3CCN\C(=N/C#N)c23)-c2cccc(OC)c2)c1

InChI Key: InChIKey=FEGVPANZWXSUTP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50256143 (CHEMBL4079300) Show SMILES COc1cccc(Nc2cc(nc3CCN\C(=N/C#N)c23)-c2cccc(OC)c2)c1 Show InChI InChI=1S/C23H21N5O2/c1-29-17-7-3-5-15(11-17)20-13-21(27-16-6-4-8-18(12-16)30-2)22-19(28-20)9-10-25-23(22)26-14-24/h3-8,11-13H,9-10H2,1-2H3,(H,25,26)(H,27,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de Curated by ChEMBL					Assay Description Inhibition of Vascular endothelial growth factor receptor 2				J Med Chem 61: 2472-2489 (2018) Article DOI: 10.1021/acs.jmedchem.7b01751 BindingDB Entry DOI: 10.7270/Q2HQ42BB
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