BindingDB logo
myBDB logout

null

SMILES: COc1cccc(Nc2cc(nc3CCNC(=O)c23)-c2cccc(OC)c2)c1

InChI Key: InChIKey=XAODGTFYXXESLE-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256180   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256180
PNG
(CHEMBL4069223)
Show SMILES COc1cccc(Nc2cc(nc3CCNC(=O)c23)-c2cccc(OC)c2)c1
Show InChI InChI=1S/C22H21N3O3/c1-27-16-7-3-5-14(11-16)19-13-20(21-18(25-19)9-10-23-22(21)26)24-15-6-4-8-17(12-15)28-2/h3-8,11-13H,9-10H2,1-2H3,(H,23,26)(H,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.40n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair