BindingDB PrimarySearch

BDBM50256713 3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-1,6-naphthyridin-5(6H)-one::CHEMBL262341::CHEMBL507130

SMILES: O=c1[nH]ccc2nc(-c3ccc(CN4CCC(CC4)c4nnc([nH]4)-c4ccccn4)cc3)c(cc12)-c1ccccc1

InChI Key: InChIKey=BTUWHHFNOHVCMQ-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50256713
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in HEK cells by competitive radioligand binding assay				Bioorg Med Chem Lett 19: 834-6 (2009) Article DOI: 10.1016/j.bmcl.2008.12.017 BindingDB Entry DOI: 10.7270/Q2PR7VT5
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	266	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 by cell-based assay				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt3				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 by cell-based assay				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair