BDBM50256740 2-(N-methyl-N-phenylamino)-N-((5-chloro-8-hydroxyquinolin-7-yl)(3-fluorophenyl)methyl)acetamide::CHEMBL474201

SMILES: CN(CC(=O)NC(c1cccc(F)c1)c1cc(Cl)c2cccnc2c1O)c1ccccc1

InChI Key: InChIKey=SCNAWHFIKKBCAN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256740   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM50256740 (2-(N-methyl-N-phenylamino)-N-((5-chloro-8-hydroxyq...) Show SMILES CN(CC(=O)NC(c1cccc(F)c1)c1cc(Cl)c2cccnc2c1O)c1ccccc1 Show InChI InChI=1S/C25H21ClFN3O2/c1-30(18-9-3-2-4-10-18)15-22(31)29-23(16-7-5-8-17(27)13-16)20-14-21(26)19-11-6-12-28-24(19)25(20)32/h2-14,23,32H,15H2,1H3,(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of ADAMTS5 by FRET assay				Bioorg Med Chem Lett 18: 6454-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.065 BindingDB Entry DOI: 10.7270/Q25H7G34
					More data for this Ligand-Target Pair