BDBM50257335 CHEMBL492916::trans-[2-(2-Bromophenyl)cyclopropyl]methylamine Hydrochloride

SMILES: NCC1CC1c1ccccc1Br

InChI Key: InChIKey=WYOKWGHFWKWDEZ-UHFFFAOYSA-N

Data: 6 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50257335   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5HT2B receptor				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	124	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]mesulergine from 5HT2C receptor (unknown origin)				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	655	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human 5HT2A receptor				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.72E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]citalopram from SERT (unknown origin)				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.73E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]nisoxetine from NET (unknown origin)				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]WIN35428 from DAT (unknown origin)				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.80	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50257335 (CHEMBL492916 | trans-[2-(2-Bromophenyl)cyclopropyl...) Show SMILES NCC1CC1c1ccccc1Br Show InChI InChI=1S/C10H12BrN/c11-10-4-2-1-3-8(10)9-5-7(9)6-12/h1-4,7,9H,5-6,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	94	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay				J Med Chem 52: 1885-902 (2009) Article DOI: 10.1021/jm801354e BindingDB Entry DOI: 10.7270/Q2DB81R3
					More data for this Ligand-Target Pair