BDBM50257478 2-(4'-Hydroxyphenyl)-3-[(4''carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one::CHEMBL494537
SMILES: OC(=O)c1ccc(cc1O)-c1ccc(Cc2c(oc3ccccc3c2=O)-c2ccc(O)cc2)cc1
InChI Key: InChIKey=RLZLKCASKCHDTQ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50257478 (2-(4'-Hydroxyphenyl)-3-[(4''carboxy-3''-hydroxy-1,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM50257478 (2-(4'-Hydroxyphenyl)-3-[(4''carboxy-3''-hydroxy-1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned PTP1B expressed in Escherichia coli TB1 | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50257478 (2-(4'-Hydroxyphenyl)-3-[(4''carboxy-3''-hydroxy-1,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair |