BDBM50257548 CHEMBL4104081

SMILES: O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F

InChI Key: InChIKey=YJJYVESVSULNDF-WKILWMFISA-N

Data: 1 KI  1 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257548   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257548 (CHEMBL4104081) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F |r,wU:4.7,wD:1.0,(25.74,-27.82,;25.74,-26.28,;27.08,-25.52,;27.09,-23.97,;25.76,-23.21,;24.42,-23.97,;24.41,-25.5,;25.76,-21.67,;27.09,-20.9,;28.43,-21.67,;29.76,-20.9,;29.76,-19.35,;28.42,-18.59,;27.09,-19.36,;25.76,-18.59,;31.08,-18.58,;32.42,-19.35,;33.75,-18.58,;33.75,-17.03,;34.89,-16,;36.4,-16.31,;36.88,-17.77,;36.57,-19.28,;38.03,-18.8,;34.26,-14.59,;32.73,-14.76,;32.41,-16.27,;31.08,-17.04,;29.74,-16.27,;29.74,-14.73,;28.41,-17.05,;28.4,-15.5,)| Show InChI InChI=1S/C23H24ClF3N4O/c24-18-12-14(3-8-19(18)28-15-4-6-16(32)7-5-15)17-9-10-31-20(11-13-1-2-13)29-30-22(31)21(17)23(25,26)27/h3,8-10,12-13,15-16,28,32H,1-2,4-7,11H2/t15-,16-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257548 (CHEMBL4104081) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F |r,wU:4.7,wD:1.0,(25.74,-27.82,;25.74,-26.28,;27.08,-25.52,;27.09,-23.97,;25.76,-23.21,;24.42,-23.97,;24.41,-25.5,;25.76,-21.67,;27.09,-20.9,;28.43,-21.67,;29.76,-20.9,;29.76,-19.35,;28.42,-18.59,;27.09,-19.36,;25.76,-18.59,;31.08,-18.58,;32.42,-19.35,;33.75,-18.58,;33.75,-17.03,;34.89,-16,;36.4,-16.31,;36.88,-17.77,;36.57,-19.28,;38.03,-18.8,;34.26,-14.59,;32.73,-14.76,;32.41,-16.27,;31.08,-17.04,;29.74,-16.27,;29.74,-14.73,;28.41,-17.05,;28.4,-15.5,)| Show InChI InChI=1S/C23H24ClF3N4O/c24-18-12-14(3-8-19(18)28-15-4-6-16(32)7-5-15)17-9-10-31-20(11-13-1-2-13)29-30-22(31)21(17)23(25,26)27/h3,8-10,12-13,15-16,28,32H,1-2,4-7,11H2/t15-,16-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.30	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257548 (CHEMBL4104081) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F |r,wU:4.7,wD:1.0,(25.74,-27.82,;25.74,-26.28,;27.08,-25.52,;27.09,-23.97,;25.76,-23.21,;24.42,-23.97,;24.41,-25.5,;25.76,-21.67,;27.09,-20.9,;28.43,-21.67,;29.76,-20.9,;29.76,-19.35,;28.42,-18.59,;27.09,-19.36,;25.76,-18.59,;31.08,-18.58,;32.42,-19.35,;33.75,-18.58,;33.75,-17.03,;34.89,-16,;36.4,-16.31,;36.88,-17.77,;36.57,-19.28,;38.03,-18.8,;34.26,-14.59,;32.73,-14.76,;32.41,-16.27,;31.08,-17.04,;29.74,-16.27,;29.74,-14.73,;28.41,-17.05,;28.4,-15.5,)| Show InChI InChI=1S/C23H24ClF3N4O/c24-18-12-14(3-8-19(18)28-15-4-6-16(32)7-5-15)17-9-10-31-20(11-13-1-2-13)29-30-22(31)21(17)23(25,26)27/h3,8-10,12-13,15-16,28,32H,1-2,4-7,11H2/t15-,16-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair