BDBM50258333 3-Cyano-N-(6-methylpyridin-2-yl)-4-(naphthalen-1-yl)-benzamide::CHEMBL522507

SMILES: Cc1cccc(NC(=O)c2ccc(c(c2)C#N)-c2cccc3ccccc23)n1

InChI Key: InChIKey=YTBWQFAKJAKPCW-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258333   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50258333 (3-Cyano-N-(6-methylpyridin-2-yl)-4-(naphthalen-1-y...) Show SMILES Cc1cccc(NC(=O)c2ccc(c(c2)C#N)-c2cccc3ccccc23)n1 Show InChI InChI=1S/C24H17N3O/c1-16-6-4-11-23(26-16)27-24(28)18-12-13-21(19(14-18)15-25)22-10-5-8-17-7-2-3-9-20(17)22/h2-14H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation counting				J Med Chem 52: 3563-75 (2009) Article DOI: 10.1021/jm900172f BindingDB Entry DOI: 10.7270/Q2K937FV
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50258333 (3-Cyano-N-(6-methylpyridin-2-yl)-4-(naphthalen-1-y...) Show SMILES Cc1cccc(NC(=O)c2ccc(c(c2)C#N)-c2cccc3ccccc23)n1 Show InChI InChI=1S/C24H17N3O/c1-16-6-4-11-23(26-16)27-24(28)18-12-13-21(19(14-18)15-25)22-10-5-8-17-7-2-3-9-20(17)22/h2-14H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...				J Med Chem 52: 3563-75 (2009) Article DOI: 10.1021/jm900172f BindingDB Entry DOI: 10.7270/Q2K937FV
					More data for this Ligand-Target Pair