BDBM50258922 CHEMBL4082199

SMILES: COCC(NC(=O)N1CC(=O)Nc2ccc(C)nc12)c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=VBVUNZDEYNJCEG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258922   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50258922 (CHEMBL4082199) Show SMILES COCC(NC(=O)N1CC(=O)Nc2ccc(C)nc12)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4O4/c1-11-3-8-14-17(23-11)26(9-16(27)24-14)18(28)25-15(10-29-2)12-4-6-13(7-5-12)30-19(20,21)22/h3-8,15H,9-10H2,1-2H3,(H,24,27)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay				J Med Chem 60: 7677-7702 (2017) Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR
					More data for this Ligand-Target Pair