BDBM50258925 CHEMBL4093680

SMILES: COCC(NC(=O)N1CC(=O)Nc2cc(Cl)cnc12)c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=VKTADONLSLLGMS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258925   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50258925 (CHEMBL4093680) Show SMILES COCC(NC(=O)N1CC(=O)Nc2cc(Cl)cnc12)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C18H16ClF3N4O4/c1-29-9-14(10-2-4-12(5-3-10)30-18(20,21)22)25-17(28)26-8-15(27)24-13-6-11(19)7-23-16(13)26/h2-7,14H,8-9H2,1H3,(H,24,27)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay				J Med Chem 60: 7677-7702 (2017) Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR
					More data for this Ligand-Target Pair