BDBM50258927 CHEMBL4085934

SMILES: COCC(NC(=O)N1CC(=O)Nc2cc(OC(C)C)cnc12)c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=CSKDMDLRDNEDQP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50258927 (CHEMBL4085934) Show SMILES COCC(NC(=O)N1CC(=O)Nc2cc(OC(C)C)cnc12)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C21H23F3N4O5/c1-12(2)32-15-8-16-19(25-9-15)28(10-18(29)26-16)20(30)27-17(11-31-3)13-4-6-14(7-5-13)33-21(22,23)24/h4-9,12,17H,10-11H2,1-3H3,(H,26,29)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay				J Med Chem 60: 7677-7702 (2017) Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR
					More data for this Ligand-Target Pair