BDBM50258931 CHEMBL4102271

SMILES: CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1cccc(OC(F)(F)F)c1

InChI Key: InChIKey=IQWVMJBAWVBOCY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258931   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50258931 (CHEMBL4102271) Show SMILES CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C18H17F3N4O3/c1-2-13(11-5-3-6-12(9-11)28-18(19,20)21)24-17(27)25-10-15(26)23-14-7-4-8-22-16(14)25/h3-9,13H,2,10H2,1H3,(H,23,26)(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay				J Med Chem 60: 7677-7702 (2017) Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR
					More data for this Ligand-Target Pair