BDBM50258934 CHEMBL4089762

SMILES: CCC(NC(=O)c1cnn2nc(C)cnc12)c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=IJTLFAIKVFZHFJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50258934 (CHEMBL4089762) Show SMILES CCC(NC(=O)c1cnn2nc(C)cnc12)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C17H16F3N5O2/c1-3-14(11-4-6-12(7-5-11)27-17(18,19)20)23-16(26)13-9-22-25-15(13)21-8-10(2)24-25/h4-9,14H,3H2,1-2H3,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay				J Med Chem 60: 7677-7702 (2017) Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR
					More data for this Ligand-Target Pair