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BDBM50262433 CHEMBL4093257

SMILES: CC(C)Nc1nc(NCc2cccnc2)c2sc(cc2n1)-c1ccccc1

InChI Key: InChIKey=QXGVXXWQESOXFR-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50262433   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Atrial natriuretic peptide receptor


(Homo sapiens (Human))		BDBM50262433
PNG
(CHEMBL4093257)
Show SMILES CC(C)Nc1nc(NCc2cccnc2)c2sc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C21H21N5S/c1-14(2)24-21-25-17-11-18(16-8-4-3-5-9-16)27-19(17)20(26-21)23-13-15-7-6-10-22-12-15/h3-12,14H,13H2,1-2H3,(H2,23,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 7.90E+3n/an/an/an/a



Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...

Bioorg Med Chem Lett 27: 4904-4907 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J
More data for this
Ligand-Target Pair