BDBM50262457 CHEMBL4101571

SMILES: CC(C)Nc1nc(NCc2ccc(NC(=O)C3CCCN(C)C3)cc2)c2cc(ccc2n1)-c1ccccc1

InChI Key: InChIKey=HUAAPRXOZJKMRK-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50262457   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Atrial natriuretic peptide receptor (Homo sapiens (Human))	BDBM50262457 (CHEMBL4101571) Show SMILES CC(C)Nc1nc(NCc2ccc(NC(=O)C3CCCN(C)C3)cc2)c2cc(ccc2n1)-c1ccccc1 Show InChI InChI=1S/C31H36N6O/c1-21(2)33-31-35-28-16-13-24(23-8-5-4-6-9-23)18-27(28)29(36-31)32-19-22-11-14-26(15-12-22)34-30(38)25-10-7-17-37(3)20-25/h4-6,8-9,11-16,18,21,25H,7,10,17,19-20H2,1-3H3,(H,34,38)(H2,32,33,35,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp. Curated by ChEMBL					Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...				Bioorg Med Chem Lett 27: 4904-4907 (2017) Article DOI: 10.1016/j.bmcl.2017.09.028 BindingDB Entry DOI: 10.7270/Q279475J
					More data for this Ligand-Target Pair