BDBM50262513 CHEMBL449277::cis-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquinolin-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitrile
SMILES: FCCCOc1ccc2CN(CCc2c1)[C@H]1CC[C@H](CC1)c1c[nH]c2ccc(cc12)C#N
InChI Key: InChIKey=OIJZGDHTGREJNF-UHGJSFDGSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50262513 (CHEMBL449277 | cis-3-(4-(6-(3-fluoropropoxy)-3,4-d...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung Curated by ChEMBL | Assay Description Displacement of [3H]citalopram from human SERT expressed in HEK293 cells | Bioorg Med Chem Lett 18: 4727-30 (2008) Article DOI: 10.1016/j.bmcl.2008.06.077 BindingDB Entry DOI: 10.7270/Q2M61K2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50262513 (CHEMBL449277 | cis-3-(4-(6-(3-fluoropropoxy)-3,4-d...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 366 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung Curated by ChEMBL | Assay Description Displacement of [3H]WIN35428 from human DAT expressed in HEK293 cells | Bioorg Med Chem Lett 18: 4727-30 (2008) Article DOI: 10.1016/j.bmcl.2008.06.077 BindingDB Entry DOI: 10.7270/Q2M61K2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50262513 (CHEMBL449277 | cis-3-(4-(6-(3-fluoropropoxy)-3,4-d...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 772 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung Curated by ChEMBL | Assay Description Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells | Bioorg Med Chem Lett 18: 4727-30 (2008) Article DOI: 10.1016/j.bmcl.2008.06.077 BindingDB Entry DOI: 10.7270/Q2M61K2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50262513 (CHEMBL449277 | cis-3-(4-(6-(3-fluoropropoxy)-3,4-d...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 914 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung Curated by ChEMBL | Assay Description Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells | Bioorg Med Chem Lett 18: 4727-30 (2008) Article DOI: 10.1016/j.bmcl.2008.06.077 BindingDB Entry DOI: 10.7270/Q2M61K2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50262513 (CHEMBL449277 | cis-3-(4-(6-(3-fluoropropoxy)-3,4-d...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membrane | Bioorg Med Chem Lett 18: 4727-30 (2008) Article DOI: 10.1016/j.bmcl.2008.06.077 BindingDB Entry DOI: 10.7270/Q2M61K2K | |||||||||||
More data for this Ligand-Target Pair |