BDBM50262834 2,6-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone::CHEMBL478406

SMILES: Cc1ccc2nc(C)n(-c3ccc(OCCCN4CCCC4)cc3)c(=O)c2c1

InChI Key: InChIKey=WZRDTUYSOKIWCB-UHFFFAOYSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50262834   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50262834 (2,6-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}p...) Show SMILES Cc1ccc2nc(C)n(-c3ccc(OCCCN4CCCC4)cc3)c(=O)c2c1 Show InChI InChI=1S/C23H27N3O2/c1-17-6-11-22-21(16-17)23(27)26(18(2)24-22)19-7-9-20(10-8-19)28-15-5-14-25-12-3-4-13-25/h6-11,16H,3-5,12-15H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bioprojet-Biotech Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assay				Bioorg Med Chem Lett 21: 5378-83 (2011) Article DOI: 10.1016/j.bmcl.2011.07.006 BindingDB Entry DOI: 10.7270/Q2VX0GXK
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50262834 (2,6-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}p...) Show SMILES Cc1ccc2nc(C)n(-c3ccc(OCCCN4CCCC4)cc3)c(=O)c2c1 Show InChI InChI=1S/C23H27N3O2/c1-17-6-11-22-21(16-17)23(27)26(18(2)24-22)19-7-9-20(10-8-19)28-15-5-14-25-12-3-4-13-25/h6-11,16H,3-5,12-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bioprojet-Biotech Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay				Bioorg Med Chem Lett 21: 5378-83 (2011) Article DOI: 10.1016/j.bmcl.2011.07.006 BindingDB Entry DOI: 10.7270/Q2VX0GXK
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50262834 (2,6-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}p...) Show SMILES Cc1ccc2nc(C)n(-c3ccc(OCCCN4CCCC4)cc3)c(=O)c2c1 Show InChI InChI=1S/C23H27N3O2/c1-17-6-11-22-21(16-17)23(27)26(18(2)24-22)19-7-9-20(10-8-19)28-15-5-14-25-12-3-4-13-25/h6-11,16H,3-5,12-15H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO-K1 cells				J Med Chem 51: 4780-9 (2008) Article DOI: 10.1021/jm8003834 BindingDB Entry DOI: 10.7270/Q2FQ9WFW
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50262834 (2,6-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}p...) Show SMILES Cc1ccc2nc(C)n(-c3ccc(OCCCN4CCCC4)cc3)c(=O)c2c1 Show InChI InChI=1S/C23H27N3O2/c1-17-6-11-22-21(16-17)23(27)26(18(2)24-22)19-7-9-20(10-8-19)28-15-5-14-25-12-3-4-13-25/h6-11,16H,3-5,12-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]meth...				J Med Chem 51: 4780-9 (2008) Article DOI: 10.1021/jm8003834 BindingDB Entry DOI: 10.7270/Q2FQ9WFW
					More data for this Ligand-Target Pair