BDBM50263357 CHEMBL478434::trans-7'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide
SMILES: COc1cccc2C(=O)O[C@]3(CC[C@@H](CC3)C(=O)N(C)CCN3CCCCC3)c12
InChI Key: InChIKey=HTAUIWGHWGTTSA-QBNMFFNISA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50263357 (CHEMBL478434 | trans-7'-Methoxy-3'-oxo-3'H-spiro[c...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS binding | Bioorg Med Chem Lett 18: 5101-6 (2008) Article DOI: 10.1016/j.bmcl.2008.07.125 BindingDB Entry DOI: 10.7270/Q2PC3268 | |||||||||||
More data for this Ligand-Target Pair |