BDBM50263453 CHEMBL4065219

SMILES: CN1C(=O)C2CN(Cc3c2c2ccccc2n3Cc2ccc(\C=C\C(=O)NO)cc2)C1=O

InChI Key: InChIKey=USYSIRQEIVMRRQ-ZHACJKMWSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50263453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50263453 (CHEMBL4065219) Show SMILES CN1C(=O)C2CN(Cc3c2c2ccccc2n3Cc2ccc(\C=C\C(=O)NO)cc2)C1=O Show InChI InChI=1S/C24H22N4O4/c1-26-23(30)18-13-27(24(26)31)14-20-22(18)17-4-2-3-5-19(17)28(20)12-16-8-6-15(7-9-16)10-11-21(29)25-32/h2-11,18,32H,12-14H2,1H3,(H,25,29)/b11-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as subst...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50263453 (CHEMBL4065219) Show SMILES CN1C(=O)C2CN(Cc3c2c2ccccc2n3Cc2ccc(\C=C\C(=O)NO)cc2)C1=O Show InChI InChI=1S/C24H22N4O4/c1-26-23(30)18-13-27(24(26)31)14-20-22(18)17-4-2-3-5-19(17)28(20)12-16-8-6-15(7-9-16)10-11-21(29)25-32/h2-11,18,32H,12-14H2,1H3,(H,25,29)/b11-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	67	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as substrate...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50263453 (CHEMBL4065219) Show SMILES CN1C(=O)C2CN(Cc3c2c2ccccc2n3Cc2ccc(\C=C\C(=O)NO)cc2)C1=O Show InChI InChI=1S/C24H22N4O4/c1-26-23(30)18-13-27(24(26)31)14-20-22(18)17-4-2-3-5-19(17)28(20)12-16-8-6-15(7-9-16)10-11-21(29)25-32/h2-11,18,32H,12-14H2,1H3,(H,25,29)/b11-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	205	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair