BDBM50263460 CHEMBL4084164

SMILES: ONC(=O)\C=C\c1ccc(Cn2c3C4CCCC(=O)N4CCc3c3ccccc23)cc1

InChI Key: InChIKey=XIEDZYSMTIAQIH-OUKQBFOZSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50263460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50263460 (CHEMBL4084164) Show SMILES ONC(=O)\C=C\c1ccc(Cn2c3C4CCCC(=O)N4CCc3c3ccccc23)cc1 Show InChI InChI=1S/C25H25N3O3/c29-23(26-31)13-12-17-8-10-18(11-9-17)16-28-21-5-2-1-4-19(21)20-14-15-27-22(25(20)28)6-3-7-24(27)30/h1-2,4-5,8-13,22,31H,3,6-7,14-16H2,(H,26,29)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as subst...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50263460 (CHEMBL4084164) Show SMILES ONC(=O)\C=C\c1ccc(Cn2c3C4CCCC(=O)N4CCc3c3ccccc23)cc1 Show InChI InChI=1S/C25H25N3O3/c29-23(26-31)13-12-17-8-10-18(11-9-17)16-28-21-5-2-1-4-19(21)20-14-15-27-22(25(20)28)6-3-7-24(27)30/h1-2,4-5,8-13,22,31H,3,6-7,14-16H2,(H,26,29)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	234	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as substrate...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50263460 (CHEMBL4084164) Show SMILES ONC(=O)\C=C\c1ccc(Cn2c3C4CCCC(=O)N4CCc3c3ccccc23)cc1 Show InChI InChI=1S/C25H25N3O3/c29-23(26-31)13-12-17-8-10-18(11-9-17)16-28-21-5-2-1-4-19(21)20-14-15-27-22(25(20)28)6-3-7-24(27)30/h1-2,4-5,8-13,22,31H,3,6-7,14-16H2,(H,26,29)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair