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BDBM50263466 CHEMBL4100615

SMILES: CN1C(=O)C2CN(Cc3c2c2ccc4ccccc4c2n3Cc2ccc(cc2)C(=O)NO)C1=O

InChI Key: InChIKey=UCCGFQJVFMUYJR-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50263466   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))		BDBM50263466
PNG
(CHEMBL4100615)
Show SMILES CN1C(=O)C2CN(Cc3c2c2ccc4ccccc4c2n3Cc2ccc(cc2)C(=O)NO)C1=O
Show InChI InChI=1S/C26H22N4O4/c1-28-25(32)20-13-29(26(28)33)14-21-22(20)19-11-10-16-4-2-3-5-18(16)23(19)30(21)12-15-6-8-17(9-7-15)24(31)27-34/h2-11,20,34H,12-14H2,1H3,(H,27,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
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AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.80n/an/an/an/an/an/an/an/a



Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as subst...

J Med Chem 61: 3454-3477 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01593
BindingDB Entry DOI: 10.7270/Q24B33S0
More data for this
Ligand-Target Pair