BDBM50263480 CHEMBL4081647

SMILES: OC(=O)C(F)(F)F.ONC(=O)c1ccc(Cn2c3CN4CCC(C4)c3c3ccccc23)cc1

InChI Key: InChIKey=QCDLGHQIVIYWPZ-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50263480   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50263480 (CHEMBL4081647) Show SMILES OC(=O)C(F)(F)F.ONC(=O)c1ccc(Cn2c3CN4CCC(C4)c3c3ccccc23)cc1 Show InChI InChI=1S/C21H21N3O2.C2HF3O2/c25-21(22-26)15-7-5-14(6-8-15)11-24-18-4-2-1-3-17(18)20-16-9-10-23(12-16)13-19(20)24;3-2(4,5)1(6)7/h1-8,16,26H,9-13H2,(H,22,25);(H,6,7)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as subst...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50263480 (CHEMBL4081647) Show SMILES OC(=O)C(F)(F)F.ONC(=O)c1ccc(Cn2c3CN4CCC(C4)c3c3ccccc23)cc1 Show InChI InChI=1S/C21H21N3O2.C2HF3O2/c25-21(22-26)15-7-5-14(6-8-15)11-24-18-4-2-1-3-17(18)20-16-9-10-23(12-16)13-19(20)24;3-2(4,5)1(6)7/h1-8,16,26H,9-13H2,(H,22,25);(H,6,7)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50263480 (CHEMBL4081647) Show SMILES OC(=O)C(F)(F)F.ONC(=O)c1ccc(Cn2c3CN4CCC(C4)c3c3ccccc23)cc1 Show InChI InChI=1S/C21H21N3O2.C2HF3O2/c25-21(22-26)15-7-5-14(6-8-15)11-24-18-4-2-1-3-17(18)20-16-9-10-23(12-16)13-19(20)24;3-2(4,5)1(6)7/h1-8,16,26H,9-13H2,(H,22,25);(H,6,7)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Faculty of Chemistry and Pharmacy , University of Regensburg , 93040 Regensburg , Germany. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as substrate...				J Med Chem 61: 3454-3477 (2018) Article DOI: 10.1021/acs.jmedchem.7b01593 BindingDB Entry DOI: 10.7270/Q24B33S0
					More data for this Ligand-Target Pair