BDBM50263765 CHEMBL4074834

SMILES: COc1ccc(cn1)-c1c(c(C)nn1C)-c1nc(C)c2n1nc(C)[nH]c2=O

InChI Key: InChIKey=FNNBECNCZHVYKP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50263765   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50263765 (CHEMBL4074834) Show SMILES COc1ccc(cn1)-c1c(c(C)nn1C)-c1nc(C)c2n1nc(C)[nH]c2=O |(17.03,-22.44,;17.8,-21.11,;19.35,-21.11,;20.11,-19.77,;21.66,-19.77,;22.43,-21.11,;21.66,-22.44,;20.11,-22.44,;23.97,-21.11,;24.88,-19.86,;26.34,-20.33,;27.59,-19.43,;26.34,-21.88,;24.88,-22.35,;24.4,-23.82,;24.4,-18.39,;25.31,-17.14,;24.4,-15.9,;24.88,-14.43,;22.93,-16.37,;22.93,-17.92,;21.6,-18.69,;20.26,-17.92,;18.93,-18.69,;20.26,-16.37,;21.6,-15.61,;21.6,-14.06,)| Show InChI InChI=1S/C18H19N7O2/c1-9-14(16(24(4)22-9)12-6-7-13(27-5)19-8-12)17-20-10(2)15-18(26)21-11(3)23-25(15)17/h6-8H,1-5H3,(H,21,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human PDE2A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assay				J Med Chem 61: 3626-3640 (2018) Article DOI: 10.1021/acs.jmedchem.8b00116 BindingDB Entry DOI: 10.7270/Q2BV7K2X
					More data for this Ligand-Target Pair