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SMILES: COc1ccc(Cc2nn3c(nc(C)c3c(=O)[nH]2)[C@@H](CCC(=O)c2ccccc2)[C@H](C)O)cc1OC

InChI Key: InChIKey=WZHZQMICTSHGDO-PXNSSMCTSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50263788   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50263788
PNG
(CHEMBL4064040)
Show SMILES COc1ccc(Cc2nn3c(nc(C)c3c(=O)[nH]2)[C@@H](CCC(=O)c2ccccc2)[C@H](C)O)cc1OC |r|
Show InChI InChI=1S/C27H30N4O5/c1-16-25-27(34)29-24(15-18-10-13-22(35-3)23(14-18)36-4)30-31(25)26(28-16)20(17(2)32)11-12-21(33)19-8-6-5-7-9-19/h5-10,13-14,17,20,32H,11-12,15H2,1-4H3,(H,29,30,34)/t17-,20-/m0/s1
PDB

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PC cid
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UniChem

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PDE2A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assay

J Med Chem 61: 3626-3640 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00116
BindingDB Entry DOI: 10.7270/Q2BV7K2X
More data for this
Ligand-Target Pair