BDBM50264014 3-Oxo-3,4-dihydro-2H-spiro[isoquinoline-1,4'-piperidine]-1'-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide::CHEMBL522117

SMILES: CN(CCN1CCCCC1)C(=O)N1CCC2(CC1)NC(=O)Cc1ccccc21

InChI Key: InChIKey=CAFBJJWILSUHGZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264014   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50264014 (3-Oxo-3,4-dihydro-2H-spiro[isoquinoline-1,4'-piper...) Show SMILES CN(CCN1CCCCC1)C(=O)N1CCC2(CC1)NC(=O)Cc1ccccc21 Show InChI InChI=1S/C22H32N4O2/c1-24(15-16-25-11-5-2-6-12-25)21(28)26-13-9-22(10-14-26)19-8-4-3-7-18(19)17-20(27)23-22/h3-4,7-8H,2,5-6,9-17H2,1H3,(H,23,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	783	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 18: 5101-6 (2008) Article DOI: 10.1016/j.bmcl.2008.07.125 BindingDB Entry DOI: 10.7270/Q2PC3268
					More data for this Ligand-Target Pair