BDBM50264020 CHEMBL489770::GNF-PF-4773::N-(4-(pyridin-2-yl)thiazol-2-yl)pyridin-2-amine::TCMDC-124275::US9034574, I

SMILES: N(c1nc(cs1)-c1ccccn1)c1ccccn1

InChI Key: InChIKey=RYCUBTFYRLAMFA-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50264020   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Small conductance calcium-activated potassium channel protein 3 (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins University US Patent					Assay Description DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...				US Patent US9034574 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SSN
					More data for this Ligand-Target Pair
Methyl-CpG binding domain protein 2 (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins University US Patent					Assay Description DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...				US Patent US9034574 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SSN
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	543	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cells				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3) (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1 (KCa2.1) (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3) (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	543	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3) (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair